Antimicrobial Resistance Centre

Inspiring innovation in AMR research through interdisciplinary and international engagements.

About the Antimicrobial Resistance (AMR) Centre

AMR is a threat to life and healthcare globally. With increasing levels of international concern about AMR, we need high quality research and evidence to guide action. The London School of Hygiene & Tropical Medicine is unique in the breadth of disciplines used to meet this complex challenge. These range from microbiology and clinical medicine to social studies and economics. The School’s Antimicrobial Resistance Centre, launched in 2016, will foster connections between these scientific approaches, generating innovative approaches to science and policy.

The Centre is based on five disciplinary pillars:

The aims of the AMR Centre are:

  1. Promote and facilitate high quality research into AMR that builds on and exploits disciplinary strengths across LSHTM.
  2. Facilitate AMR related funding responses and collaboration opportunities.
  3. Provide an interface for LSHTM’s AMR research for staff, public, press and wider research communities.
  4. Provide educational materials on AMR.

Can active case detection help to eliminate multidrug resistant malaria in Cambodia?

The spread of resistance of P. falciparum malaria parasites to artemisinins is one of the biggest threats to global malaria control and elimination, and has the potential to result in millions of deaths, mainly in African children.    Cambodia, which is at the epicentre of antimalarial drug resistant malaria, declared a goal of eliminating malaria by 2025.  However there are lots of questions about how to achieve this operationally.

Watch the video

Spotlight 18/06/18 | FIEBRE launches first two study sites

The past few weeks, members of the FIEBRE study collaboration have been working together to begin study activities at the first two sites: Harare, Zimbabwe, with colleagues from the Biomedical Research and Training Institute (BRTI), and Chikwawa, Malawi, with the Malawi–Wellcome Trust team.

FIEBRE’s primary objectives are to identify the leading infectious causes of fever among patients at five sites across sub-Saharan Africa and Southeast Asia; and to determine the prevalence and spectrum of antimicrobial resistance among bacteria isolated from these patients. Fever is one of the most common symptoms leading to health care seeking and hospital admission in areas represented by FIEBRE study sites. However, many febrile illnesses present with non-specific symptoms and signs, a challenge for health care workers that is compounded by limited availability of diagnostic tools. As a result, treatable infections may be missed, or treated with inappropriate antimicrobials, on the one hand; and on the other hand, self-limiting conditions (e.g. many viral illnesses) may be over-treated with antimicrobials on the other – all with implications for the development of antimicrobial resistance (AMR).

Read more.

As well as using the links above, you can keep up to date with the study by following @FeverStudies on Twitter.

Metrics and Methods for Assessing Antibiotic Use – Roundtable

In late November 2017, the AMR Centre hosted 38 researchers, health and policy professionals in London for a roundtable to discuss how best antibiotic use can be measured in a way that informs strategies to address antibiotic resistance both nationally and internationally.

Read about the roundtable discussion here.

AMR resources

ABU on Farms
The AACTING Consortium has published Guidelines for the collection, analysis and reporting of farm-level antimicrobial use, in the scope of antimicrobial stewardship.
Stewardship Book
BSAC has published a new free e-book on Antimicrobial Stewardship. The book “provides a GLOBAL and highly PRACTICAL primer on the wise use of ANTIBIOTICS by applying the principles of stewardship to a wide range of professions, populations, and clinical/care settings”

VIDEO | Rise and fall of the magic bullet

AMR Centre member Sam Willcocks walks us through the rise and fall of antibiotics, and shows us why we need to think carefully about how we harness new technology so that we can continue to do good.