Research Projects

The Fight Against Antimicrobial Resistance: Applying Theory to Practice

The aim of this seed award is to open up new perspectives on antimicrobial resistance through the application of theories from the social sciences. Substantial bodies of work have the potential for application to the problem of AMR. Through a review of literature and engagement with a range of scientists we intend to stimulate new […]

Sources, seasonality, transmission and control: Campylobacter & human behaviour in a changing environment

Social, behavioural and economic drivers of inappropriate antibiotic use by informal private healthcare providers in rural India

Personalised Risk assessment in febrile illness to optimise Real-life Management across the European Union (PERFORM)

PERFORM aims at developing new “omics” diagnostic tests to distinguish between bacterial and viral infections in febrile children. Work package 5, led by LSHTM, is responsible for conducting a comparative health services analysis and economic evaluation to evaluate the potential costs and impacts of introducing the tests in different European health system.

Multi-drug resistance in malaria under combination therapy: assessment of specific markers and development of innovative, rapid and simple diagnostics 9 (MALACTRES)

MALACTRES is a consortium of researchers aiming to tackle multi-drug resistance in malaria under combination therapy. With partners in Europe and Africa, the overall objective is to assess specific genetic markers in Plasmodium falciparum for ACT resistance and to develop innovative, rapid and simple diagnostics for malaria.

Multi-disciplinary research of drug resistance in Malaria

Modeling vaccines and AMR

Vaccination is an important weapon in our arsenal in the fight against AMR. Mathematical models are used to understand both AMR transmission and to predict the healthcare impact of vaccination strategies. However there are relatively few studies that quantify the effect of vaccines on AMR dynamics. Our work addresses this gap in our understanding to […]

Metrics and Methods for Assessing Antibiotic Use

This project addresses how best to measure antibiotic use in humans, agriculture and aquaculture in a way that informs strategies to address antibiotic resistance both nationally and internationally. This is a major challenge across different settings given the variety of antibiotics in use, the variety of sources and supply chains for antibiotics, the large size […]

Low-cost, non-commercial drug susceptibility testing of MTB

This study is a large international alliance spanning five continents and is funded by Bill & Melinda Gates Foundation and Wellcome Trust/MRC Newton Fund. Over 100,000 TB germs will be collected, many of which will be MDR-TB, from across Africa, Asia, Europe and the Americas by teams at more than a dozen centres. Each site […]

Infection prevention and control for drug-resistant tuberculosis in South Africa in the era of decentralised care: a whole systems approach

This research aims to contribute to: 1) the development of evidence-based policies for the more effective reduction of nosocomial transmission of DR-TB in health facilities in high burden settings; and 2) a paradigm shift towards IPC measures for DR-TB in health facilities that are grounded in a whole systems approach. In order to achieve this […]