Research Projects

A randomised experiment exploring antibiotic prescribing practices among private health facilities in Tanzania

This study, embedded in a wider evaluation of quality of care in private health facilities in Tanzania, aims to identify the role of patient knowledge and provider driven demand in overprescription of antibiotics.

Translating whole genome sequence technology into diagnostic and public health microbiology

I am currently working in the application of whole-genome sequencing to outbreak investigation and antimicrobial prescribing in Staphylococcus aureus. 

Application of phylogenetic statistical & computational approaches to unravel genotype – phenotype

I am currently working in the application of genome-wide association studies (GWAS) in bacteria to identify the genes that make bacteria resistant to antibiotics and able to cause infections.

Working with plantation owners to control malaria and antimalarial drug resistance

Use of transposon-directed insertion site sequencing to identify new essential drug targets

Use of herpesvirus genetics to determine pan-antimicrobial mechanism of action

Understanding health system linkages: Formative research to develop strategies to support quality improvement in treatment in the private sector

Through a specific focus on antibiotic treatment and use, this study aims to shed light on the broader processes affecting quality of care in private clinics and drug shops in Uganda. The private sector plays an important role in health care provision in many African countries and cannot be overlooked in strategies to control misuse […]

Treatment of multi-drug-resistant Acinetobacter baumannii and Klebsiella pneumonia infections using bacteriophage capsule depolymerases

This project aims to determine the capacity of depolymerases, directed against capsule polysaccharides of the most frequently encountered Thai isolates of MDR K. pneumoniae and A. baumannii, to resolve experimental systemic infections. Selection of strains for identification, purification and cloning of depolymerases with appropriate substrate specificity and for establishment of models of infection will be guided by a […]

Tracking Resistance to Artemisinin Collaboration II

The second iteration of the TRAC project, known as TRAC II, will not only monitor for the further extension or emergence of drug resistance, but will also investigate the safety, tolerability and efficacy of Triple Artemisinin-based Combination Therapies (TACTs) – the first of its kind. In areas with failing ACTs, the aim of TACTs is […]

The interactions between C. difficile, intestinal microbiota & host response in hospital patients