Seminar | Population genomics of Klebsiella pneumoniae


Kat is currently a NHMRC Career Development Fellow and Associate Professor at the University Of Melbourne, and a HHMI-Gates International Research Scholar. Kat went to the University of Cambridge to undertake a PhD in Molecular Biology at the Wellcome Trust Sanger Institute. There she studied the genomics of typhoid fever, under the supervision of Gordon Dougan, Julian Parkhill and Duncan Maskell. In 2010 Kat returned to Australia to take up an NHMRC Early Career Fellowship in the Department of Microbiology and Immunology at the University of Melbourne

Kats group uses whole genome sequencing to study populations of bacteria that contribute to infectious disease in a variety of settings. This includes in-depth studies of microevolution in specific pathogen populations, using next-generation sequencing technologies to sequence and compare the genomes of hundreds or thousands of closely related isolates of the same pathogen. In these studies, the minor differences between isolates are of interest as they reveal how the pathogen is evolving in response to selective pressures (e.g. exposure to antibiotics, vaccine-induced immunity, or natural host immunity).


Speaker: Kathryn Holt

Date: Monday 2 October, 13:00 – 14:00

Venue: LG8, Keppel Street