Research Projects

Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE)

Fever is one of the most common symptoms that leads to health-care seeking and hospital admission across sub-Saharan Africa and Asia. However, little is known about the causes of febrile illness in these regions. Without access to reliable diagnostic facilities, and without evidence on which to base treatment guidelines, in most cases treatment is empiric and […]

Faecal metagenomics on acquisition of AMR in travellers

Recent prospective studies among travellers have sought to quantify the risk of importation, and duration of colonisation, associated with travel to high risk countries and antibiotic use. Most studies have reported that persistence beyond three months of travel is unusual. However these studies have been predominantly employed culture-based methods, or used predefined primers for commoner […]

Examining the costs and cost-effectiveness of novel TB regimens

Exploring the cost-effectiveness of the introduction of new TB drugs regimens, including the corresponding costs of drug-susceptability testing to prevent resistance.

Evaluation of the UK AMR strategy, 2013-2018

The team is using a range of methods including interviews, a series of case studies, systematic reviews, focus groups and a citizens’ jury to explore implementation, and the evidence underpinning the mechanisms of change, in this complex and multi-sector intervention.

Estimating the economic burden on the health system and patient of multi-drug resistant TB in South Africa (XTEND sub-study)

Estimate the economic burden to the health system and patients of multi-drug resistant TB in South Africa.

Estimating the costs in five countries of the diagnosis and treatment of multi-drug resitance TB (VALUE-TB)

Estimate the economic burden to the health system of multi-drug resistant TB in five countries.

Economic Evaluation support to a trial that assess strategies to address anti-microbial resistance in malnourished children (FLACSAM)

Children with complicated severe acute malnutrition (SAM) admitted to hospital in sub-Saharan Africa have a case fatality of 12% to more than 20%. Because children with SAM may not exhibit the usual signs of infection, WHO guidelines recommend routine antibiotics. However, this is based on “low quality evidence”. There is evidence from CGMR-C, Kilifi and […]

Drug-resistant tuberculosis in Hlabisa sub-district: a prospective observational cohort

Defining reservoirs and transmission of antimicrobial-resistant Escherichia coli using a One Health approach

My fellowship is based on a One Health approach to investigate the origin and transmission of antimicrobial-resistant E. coli and K. pneumoniae in the UK.

Combating drug resistance through better governance of unregulated antimicrobial sellers in Cambodia: addressing stakeholder connections & perceptions

The research proposed here is for a 20-month Foundation grant applying innovative methods to understand, and develop strategies to address unresolved challenges relating to governance of a poorly characterised segment of the health system – unregulated, for-profit drug sellers. We focus on a high priority global health issue, inappropriate dispensing of antimicrobials (AMs), in one […]