Tracking Resistance to Artemisinin Collaboration II
PI: Prof Arjen Dondorp (Mahidol Oxford Tropical Medicine Research Unit)
Co-Is: Multicentered incl Shunmay Yeung at LSHTM
The second iteration of the TRAC project, known as TRAC II, will not only monitor for the further extension or emergence of drug resistance, but will also investigate the safety, tolerability and efficacy of Triple Artemisinin-based Combination Therapies (TACTs) – the first of its kind. In areas with failing ACTs, the aim of TACTs is restoring antimalarial efficacy, whereas in areas where ACTs still work or artemisinin resistance has not yet arrived, it has the potential to delay the emergence of drug resistance.
Modeling vaccines and AMR
Staff: Mark Jit, Nick Davies and Katherine Atkins
Funding: NIHR (2014-2019)
Vaccination is an important weapon in our arsenal in the fight against AMR. Mathematical models are used to understand both AMR transmission and to predict the healthcare impact of vaccination strategies. However there are relatively few studies that quantify the effect of vaccines on AMR dynamics. Our work addresses this gap in our understanding to further our knowledge on how best to quantify the impact of vaccines on AMR and how to integrate these models into public health decision making for vaccines.
Drug-resistant tuberculosis in Hlabisa sub-district: a prospective observational cohort
Staff: Lessels R.
Funding: Wellcome Trust