Treatment of multi-drug-resistant Acinetobacter baumannii and Klebsiella pneumonia infections using bacteriophage capsule depolymerases
Staff: Prof Peter Taylor (UCL), Richard Stabler (LSHTM), Nick Thomson (LSHTM/WTSI)
Funding: MRC, 2016-2019
Summary: Acinetobacter baumannii and Klebsiella pneumonia are bacteria with an amazing ability to develop resistance to antibiotics and we are on the verge of having nothing left to treat those infected. We aim to use proteins from viruses that infected the bacteria to disarm it by removing the bacterial protective coat, allowing the human immune system to remove infections.
Use of herpesvirus genetics to determine pan-antimicrobial mechanism of action
Staff: Gompels U.
Funding: HHV-6 Foundation
Use of transposon-directed insertion site sequencing to identify new essential drug targets
Staff: Willcocks S.
Funding: UK Defence Science and Technology Laboratory