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Current newsletter

6 Aug 2018

This week’s newsletter was compiled by John Manton, head of the Humanities and Environmental Sciences pillar.
 

 

Spotlight 

Interagency Coordination Group – AMR discussion papers open for feedback 

Due to report to the United Nations Secretary-General in 2019, the Interagency Coordination Group (IACG) on AMR aims ‘to provide practical guidance for approaches needed to ensure sustained effective global action to address antimicrobial resistance’. In seeking to do so, the IACG has been consulting with the World Health Organization (WHO), the Food and Agriculture Organization (FAO), and the World Organisation for Animal Health (OIE). It has looked at public awareness and communication, the production of National Action Plans on AMR, optimisation and innovation, access, governance, surveillance and monitoring, and alignment with SDGs.

Following this initial review, the IACG has to date produced two sets of discussion papers. The first set, on R&D, National Action Plans, and surveillance and monitoring, was open for consultation until early July, and consolidated comments have been issued together with a second set of papers on governance, optimisation, and bridging the gap between communication and collective action on AMR. These papers, and the consolidated comments from the first set, are available online; the consultation on these papers is open for feedback until 31 August 2018. All interested stakeholders, from state level to individual, are invited to contribute.

 

 

News: LSHTM

Save the date: Mass Drug Administration and Antimicrobial Resistance Symposium 2019

We are pleased to announce that the LSHTM AMR Centre, together with the MARCH and Malaria Centres will jointly hold the Mass Drug Administration and Antimicrobial Resistance Symposium in Keppel Street, LSHTM on 20 February 2019.

Please book it in your calendars.

Further information here

 

 

News: External

  • Submission of in-vitro diagnostics for the next edition of the EDL: The World Health Organisation recently published the procedure to update the next edition of the WHO Model List of  Essential in vitro Diagnostics List (EDL). Applications for additions, modifications and deletions of in-vitro diagnostics can be made using the form:  https://extranet.who.int/dataform/865541?lang=en . Pre-submissions should be done no later than 15 September 2018. There is an explicit expression of intertest in categories of tests for antimicrobial resistance.
  • Innovate4AMR – a student competition: Innovate4AMR invites students to come up with creative solutions that tackle how we might manage better the use of life-saving antibiotics in our hospitals, clinics and outpatient pharmacies, particularly in resource-limited settings. How can we change patient expectations of an antibiotic when faced with a viral illness not treatable by such drugs? What role might telehealth play in improving antimicrobial stewardship without local infectious disease experts? Could mobile phones enable delayed prescribing of antibiotics till the patient actually needs such treatment? How do we achieve access, but not excess in stewarding this resource in healthcare delivery? Students do not need any previous experience on antimicrobial resistance (AMR). Starter educational resources are available at: http://innovate4amr.org, together with rules, terms and conditions, and this introductory video is available to view. The deadline for projects proposals is Monday, 17 September, 2018
 

 

Pre-meeting for Mass Drug Administration and Antimicrobial Resistance Symposium

Date: Tue, 18 Sep 2018
Time: 11-12pm
Venue: LG80, Keppel Street
In advance of our planned symposium on MDA and AMR in February 2019, we are inviting anyone interested in discussing how we can shape up this symposium to a one hour meeting during LSHTM Week on 18 Sep, 11-12pm at LG80, Keppel Street. If you’re unable to join in person we can link you remotely, or communicate separately – please email amr@lshtm.ac.uk
 

 

Events: LSHTM

The AMR Centre lunchtime seminar series

AMR Centre Seminars are usually on the first Tuesday of each month at 12:45.
Please visit the Events page on our website for more information.
Upcoming seminar:

Missed a seminar?

Recordings of some of our past seminars can be accessed through the links below:

Related events

10 September 2018. Fresh perspectives: Social Research on Anti-Microbial Resistance (AMR) will bring together researchers who are attending to ‘the social’ in AMR, including anthropologists, sociologists, historians, geographers, artists, philosophers and other related scholars. While many are engaged in productive interdisciplinary work within their every day research, this symposium presents an opportunity for concentration on disciplinary work within the social sciences and humanities. Formulated as a work-in-progress event, we hope attendees will exchange ideas about approaches and theory that have been developed and applied in their on-going social research on AMR.
 

 

Events: External

The Science Museum’s exhibit on “Superbugs: the Fight for our Lives”, advised by AMR Centre members, is on-going.

3–25 August 2018. Fringe Production of The Mould That Changed the World. Alexander Fleming’s death-defying worldly-wonder antibiotic drugs have saved us for the last 90 years. But bacterial resistance is growing, doomsday approaches. What better way to fight back than with a Musical of epic proportions? The professional production of The Mould That Changed the World will run for 3 weeks at the heart of the 2018 Edinburgh Fringe Festival in the Grand Theatre at Surgeon’s Hall. It will be performed by a professional cast and live band, along with a chorus made up of healthcare professionals.

21 September 2018. Preparing sexual health services for the challenge of AMRThe British Association for Sexual Health & HIV (BASHH) are hosting a meeting on STIs and AMR in Bristol. Please click HERE for further details and you can register on the Eventbrite site, spaces are limited to 80.

23–28 September 2018. Medicine Quality and Public Health Conference, Oxford, UK. The Infectious Diseases Data Observatory (IDDO) is organising the first-ever dedicated academic conference on Medicine Quality & Public Health that will bring together people from a diversity of sectors working in this field. The deadline for registration is 31 August 2018. The final date for abstract submission is closed.

26–28 November 2018. EFFORT against antimicrobial resistance. The European EFFORT consortium will hold the International Conference “Antimicrobial Resistance in the Food Chain – From Science to Policy”. Please save the dates!

4–5 October 2018. Antimicrobial Resistance as a Social Dilemma – Interdisciplinary workshop at College Court, Leicester. The event is free but you need to register.

26–28 November 2018. EFFORT against antimicrobial resistance. The European EFFORT consortium will hold the International Conference “Antimicrobial Resistance in the Food Chain – From Science to Policy”. Please save the dates!

27-29 November 2018. Antimicrobial Resistance – Genomes, big data and emerging technologies at Wellcome Genome Campus, Hinxton, UK. This meeting will highlight the importance of Big Data and genomics in the fight against AMR. It will showcase recent advances in the rapidly emerging field of machine learning to predict AMR, approaches to monitor and evaluate the global burden of disease, novel technologies for the diagnosis of drug-resistant infections, and the use of pathogen genomics to address critical questions relating to surveillance, epidemiology, transmission and treatment of drug-resistant infections.  Registration deadline: 30 October 2018

You can visit our website for further external events that you might find of interest.

 

 

LSHTM Featured publication

Peacock, Sharon J., Julian Parkhill, and Nicholas M. Brown. Changing the Paradigm for Hospital Outbreak Detection by Leading with Genomic Surveillance of Nosocomial PathogensMicrobiology, 2018.

This review is based on the Unilever Colworth Prize awarded to Sharon Peacock in 2018 for outstanding contribution to translational microbiology. It proposes a redesign of hospital outbreak detection and investigation in which bacterial species associated with nosocomial transmission and infection undergo routine prospective whole-genome sequencing. The current paradigm for hospital outbreak detection and investigation is based on methodology first developed over 150 years ago. Daily surveillance to detect patients positive for pathogens of particular importance for nosocomial infection is supported by epidemiological investigation to determine their relationship in time and place, and to identify any other factor that could link them. The antibiotic resistance pattern is commonly used as a surrogate for bacterial relatedness, although this lacks sensitivity and specificity. Ultimately, the identification of an outbreak remains a predominately subjective process reliant on the intuition of experienced infection control professionals. Here, evidence is provided that supports a model built around prospective whole-genome sequencing, based on studies of MRSA (methicillin-resistant Staphylococcus aureus), together with the benefits of a ‘Sequence First’ approach. The feasibility of implementation is discussed, together with residual barriers that need to be overcome prior to implementation.

 

 

Publications: LSHTM

Goffau, Marcus C. de, Susanne Lager, Susannah J. Salter, Josef Wagner, Andreas Kronbichler, D. Stephen Charnock-Jones, Sharon J. Peacock, Gordon C. S. Smith, and Julian Parkhill. Recognizing the Reagent MicrobiomeNature Microbiology 3, no. 8 (August 2018): 851–53.

Köser, Claudio U., Jan Heyckendorf, Sönke Andres, Ioana D. Olaru, Thomas Schön, Erik Sturegård, Patrick Beckert, et al. ‘Reply to Dookie et Al., Whole-Genome Sequencing to Guide the Selection of Treatment for Drug-Resistant TuberculosisAntimicrobial Agents and Chemotherapy 62, no. 8 (August 2018).

Peacock, Sharon J., Julian Parkhill, and Nicholas M. Brown. Changing the Paradigm for Hospital Outbreak Detection by Leading with Genomic Surveillance of Nosocomial PathogensMicrobiology, 2018.

 

 

Submitting a grant application?

We’d love to hear from you

If you have applied for, or won, a grant award related to AMR research, please do let us know. We’d love to hear from you so that we can celebrate the hard work of our members. You can email us on: AMR@lshtm.ac.uk
 

 

Funding opportunities

Parliament seeks experts in AMR and its links to antimicrobial use in animals
The Parliamentary Office of Science and Technology (POST) is Parliament’s in-house source of scientific advice. It recently announced they will be starting research on a policy briefing on Links of antimicrobial use in animals and antimicrobial resistance in human pathogens and invites experts and academics to contribute with literature, expertise or as external reviewers.
To find out more, follow this link
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Global Challenges Research Fund Networking Grants
The scheme allows researchers from across disciplines and from developing countries and the UK to hold networking events, to forge new links and generate innovative transdisciplinary research ideas to address global challenges. We expect that these new networks will then be better equipped to apply for larger grants offered by the GCRF programme and other funding initiatives.
Deadline 8 August 2018
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PhD studentship at MRC Unit The Gambia at LSHTM Doctoral Training Program (DTP)
PhD title: “Effect of 2g of azithromycin given to women during labour on antibiotic resistance and mechanisms of gram negative bacteria”. Lead Supervisor: Dr Anna Roca, Deputy Theme Leader, Disease Control and Elimination Theme (aroca@mrc.gm) Candidates are required to submit completed application forms with supporting documents by email to training@mrc.gm
Deadline for applications: 13th August 2018.
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Small Business Research Initiative (SBRI): antimicrobial resistance (AMR) in humans
Organisations can apply to develop innovations that address the challenges of antimicrobial resistance (AMR) in humans. Strand 1 projects to last up to 12 months and have total project costs of up to £500,000 including VAT. Strand 2 projects to last between 12 and 24 months and total project costs of up to £2 million including VAT. All projects must start 1 January 2019.
Registration closes: Wednesday 22 August 2018 12:00pm
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European and Developing Countries Clinical Trials Partnership (EDCTP) Calls for Proposals
The European and Developing Countries Clinical Trials Partnership (EDCTP) has launched its 2018 calls for proposals. These include large scale clinical trials in the areas detailed below:
Advances in product development for effective prevention, treatment and management of co-infections and co-morbidities
Diagnostic tools for poverty-related diseases
Strategic action for overcoming drug resistance in malaria
Strategic action for the comparison, selection and development of malaria vaccine candidates
Vaccines for diarrhoeal diseases or lower respiratory tract infections
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Joint Global Health Trials scheme
The Department for International Development, Medical Research Council, National Institute for Health Research and Wellcome have announced the ninth call for proposals under this initiative to fund global health trials. The purpose of the scheme is to provide funding for the best proposals to generate new knowledge about interventions that will contribute to the improvement of health in low and middle-income countries. The funders particularly welcome proposals for research into chronic non-communicable diseases, including mental health and reproductive, maternal and newborn health.
The scheme funds RCTs, innovative trial methodologies and adaptive designs are welcome. In all instances, a clear justification for the chosen methodology must be provided and a clear reason for why the chosen trial design is likely to provide the most robust evidence to address the research question. For call 9, the joint funders would like to highlight an interest in funding complex interventions delivered in community settings including primary healthcare. Complex interventions must be implementable and scalable with comprehensive pilot data provided to support the proposal.
You can choose between two proposal types:

  • global health trial research grants
  • global health trial development grants

Please note the timeline for this scheme has changed. The deadline for trial development grant applications is 5 February 2019. The current call is only for the outline stage of the global health trial research grants.
Funder deadline for global health trial research grant (outline stage): 13 September 2018
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Advance notice of a BBSRC/NERC/CONCINET (Argentina) funding call for collaborative research partnerships on AMR in the environmentThe aim of the partnership is to build on existing peer-reviewed evidence to generate new knowledge and provide the deeper evidence base that can help to reduce the impact of drivers of AMR in the environment from agricultural sources as they apply to Argentina and LMICs.
A joint call for collaborative research proposals focussing on AMR in the environment is opening in October 2018.

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Please contact the Strategic Research Office for help and advice on applying for funding.

For further information on the above and other AMR funding schemes, see our website.