Latest news: External | 14 August 2017

New proposal addresses challenging market dynamics for antibiotics
A strategy that combines a market entry reward with population-based payments from insurers could provide the kind of “pull” incentive that US pharmaceutical companies need to bring new high-priority antibiotics to market, according to a new paper by a team of experts from Duke University.
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How the microbiome could tackle antibiotic resistant infections in the lungs
Miriam Moffatt, Professor of Respiratory Genetics at the National Heart and Lung Institute at Imperial College London, presented her work to shed some light on the lung microbiome and the potential to develop new treatments at a recent Academic Health Science Centre (AHSC) research workshop.
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Doctors’ Advice to Finish Antibiotics Overlooks Resistance
In his 1945 Nobel Prize lecture, Alexander Fleming included the directive, “If you use penicillin, use enough.” Some 70 years later, clinicians and researchers still aren’t always clear on what that means. Surprisingly little is known about how treatment regimens influence the emergence of antimicrobial resistance, both in individuals and in the wider human population.
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New antibiotics target
NEW specific targets for antibiotic use by farmers are on the cards and set to be revealed at RUMA’s 2017 conference, to be held on October 27 in London. Hosted in association with the Veterinary Medicines Directorate , the conference, entitled “Antibiotic resistance – facing up to the AMR challenge” is set to include the latest official antibiotic sales data for farm animals, as well as revealing the farming industry’s new sector-specific targets.
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UK poultry sector cuts antibiotic use by 50% in one year
UK poultry farmers not only halved antibiotic usage during the year to 2016 and eliminated the prophylactic use of antibiotics altogether, they did this as part of a 71% reduction in use since 2012, over a five-year period when poultry meat production increased by 11%, says the BPC.
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Crystallography provides battle-plan blueprints for attacking disease-causing bacteria
X-rays helped scientists to look under the bonnet of two common bacteria that opportunistically infect people, so as to better understand the mechanics involved. The blueprints may be used to design new drugs, which are badly needed.
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Spider peptides battle superbugs and cancer
As antibiotic resistance rises and fears over superbugs grow, scientists are looking for new treatment options. One area of focus is antimicrobial peptides (AMPs), which could someday be an alternative to currently prescribed antibiotics, many of which are becoming increasingly useless against some bacteria. Now, scientists report that they have improved the antimicrobial — and anticancer — properties of an AMP from a spider.
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Reducing risk of gut bacterial infections with next-generation probiotic?
In laboratory-grown bacterial communities, the co-administration of probiotic Lactobacillus reuteri and glycerol selectively killed C. difficile.
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New ultrafast method for determining antibiotic resistance
Researchers at Uppsala University have developed a new method for very rapidly determining whether infection-causing bacteria are resistant or susceptible to antibiotics. The findings have now been published in the U.S. journal Proceedings of the National Academy of Sciences (PNAS).
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First Fungal Disease Awareness Week Encourages Patients, Doctors to ‘Think Fungus’
The Centers for Disease Control and Prevention (CDC) announces that it has organized the first Fungal Disease Awareness Week, August 14-18, 2017, to highlight the importance of recognizing serious fungal diseases early enough to provide life-saving treatment.
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DNAe Ready to Validate Semiconductor Prototype, Direct-From-Blood Sepsis Test
Later this month, London-based DNAe expects to begin validating an integrated prototype of a semiconductor-based sepsis test that could eventually identify pathogens directly from blood within three hours.
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Even bacteria have baggage, and understanding that is key to fighting superbugs
New research points to treatment strategies for multi-drug antibiotic resistance using currently available drugs. The study demonstrates how different adaptation histories of bacterial pathogens to antibiotics leads to distinct evolutionary dynamics of multi-drug resistance.
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Magnetic fields turn up the heat on bacterial biofilms
A short exposure to an alternating magnetic field might someday replace multiple surgeries and weeks of IV antibiotics as treatment for stubborn infections on artificial joints, new research suggests.
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